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M94A0705.TXT
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1994-10-21
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Document 0705
DOCN M94A0705
TI Resistant fungal infections in AIDS--an emerging problem.
DT 9412
AU Woolley I; Fuller A; Franklin C; Hale C; Vujovic O; Russell P; Spelman
D; Spicer WJ; Department of Microbiology and Infectious Diseases,
Alfred; Hospital, Prahran.
SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:28 (abstract no. TC6).
Unique Identifier : AIDSLINE ASHM5/94348950
AB 1. CANDIDIASIS. We discuss 3 patients who developed severe symptomatic
oral candidiasis. Clinical resistance to ketoconazole and fluconazole
occurred over time, necessitating the use of intravenous amphotericin in
two patients. Disc sensitivity testing of their isolates with
Neosensitabs confirmed the resistance. 2. CRYPTOCOCCOSIS. We discuss one
patient with cryptococcaemia and not meningitis treated with fluconazole
who relapsed months later. Disc sensitivity testing of the isolate with
Neosensitabs revealed the cryptococcus was initially intermediate and
later became resistant to fluconazole. He is now being treated with
itraconazole. Fungal resistance is clearly an emerging problem in AIDS
patients. We find there is good correlation with our disc sensitivity
testing and clinical outcome.
DE Amphotericin B/*ADMINISTRATION & DOSAGE AIDS-Related Opportunistic
Infections/*DRUG THERAPY Candidiasis, Oral/*DRUG THERAPY
Cryptococcosis/*DRUG THERAPY Drug Resistance, Microbial Drug Therapy,
Combination Fluconazole/*ADMINISTRATION & DOSAGE Fungemia/*DRUG
THERAPY Human Infusions, Intravenous Itraconazole/*ADMINISTRATION &
DOSAGE Ketoconazole/*ADMINISTRATION & DOSAGE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).